CBD Side Effects and Drug Interactions

Learn more about all the potential CBD side effects and drug interactions.


CBD has been marketed as this miraculous, all-in-one treatment with high therapeutic and medicinal value. While there is a lot of scientific evidence backing many of the statements made, it is important to address the side effects and potential CBD drug interactions.

The Side Effects of CBD: Short-Term, Long-Term, and Chronic Usage

CBD is generally well-tolerated since it mirrors the same chemical compounds that are naturally-occurring within our biology. In rare cases, however, patients have reported minor side effects:

  • Fatigue
  • Dry mouth
  • Changes in appetite
  • Diarrhea

These side effects may be related to the dosage of CBD you’re intaking– experimenting with proper dosage may mitigate these symptoms. Some individuals may not tolerate a full-spectrum oil while experiencing no side effects with an oil-free isolate. Experimentation and self-discovery may help prevent side effects. There are no other side effects tied with short-term, long-term, or chronic use. CBD is regarded as a safe and non-toxic chemical compound– patients can’t develop a tolerance to it, can’t become addicted, or suffer from an overdose. Taking large amounts of CBD is safe but ultimately a waste of money and resources.

CBD and Pharmaceutical Drug Interactions

CBD and other plant-derived cannabinoids can interact with pharmaceutical and synthetic drugs. Sufficient doses of CBD temporarily deactivate cytochrome p450 enzymes. These enzymes are responsible for metabolizing approximately 60% of pharmaceutical drugs. There are other foods and medications that have this same effect: grapefruit, watercress, goldenseal, and St. John’s Wort. CBD differs from these foods and medications because, in some cases, it can actually improve the effectiveness of pharmaceuticals. For instance, when taking a full-spectrum CBD product, opiates’ therapeutic potential actually improves. The THC heightens the pain-relieving effects of opiates while CBD reduces dependence and withdrawal. In other cases, CBD’s temporary deactivation of cytochrome p450 enzymes can interfere with the effectiveness of your pharmaceuticals.

Researchers have found that if the dosage of CBD is low enough it will not affect the cytochrome p450 enzyme activity. There is, however, no established cut-off dosage– scientists are still conducting research on this matter.

Determining CBD Dosage and Drug Interactions

We always recommend speaking to your healthcare professional if you are currently taking any pharmaceutical medications and would like to incorporate CBD into your routine. Since CBD can interact so differently with various synthetic medications, your healthcare professional can help create the right plan of action for you. Taking CBD on an opposite schedule than your pharmaceuticals may be sufficient. CBD dosage varies from individual to individual making self-experimentation and consulting your healthcare professional necessary.

For more information regarding side effects or CBD drug interactions, please contact us!


Refund Policy
For best results, we recommend trying CBD for 2 weeks to feel maximum benefits, but if you are unsatisfied with this product in any way we'll give you your money back. Guaranteed! You may request a refund within 15 days of items receipt.

All of our products are completely THC-free and are legal in all 50 states.